To those who suffered from diabetes, in order to keep your blood sugar levels under control, a new ‘smart’ insulin patch could do away with all those painful injections and revolutionize the way diabetics keep their blood sugar levels in check.
The patch, created by researchers from the University of North Carolina and NC State, is a thin square covered with more than 100 tiny needles. According to researchers, the patch works fast, is simple to use and is made from biocompatible materials. The patch is a thin square –no bigger than a penny — is covered with more than one hundred tiny needles, each about the size of an eyelash. These “microneedles” are packed with microscopic storage units for insulin and glucose-sensing enzymes that rapidly release their cargo when blood sugar levels get too high.
The study, published in Proceedings of the National Academy of Sciences, showed promising results in a mouse model of type 1 diabetes. Researchers hope to see similar success in subsequent clinical trials in humans.
Around 387 million worldwide suffer from diabetes. These patients keep their blood sugar in check by monitoring their levels with regular finger pricks and repeated insulin shots. If the wrong amount of medication is injected, patients could suffer from severe complications.
The whole system can be personalized to account for a diabetic’s weight and sensitivity to insulin,” said co-senior author Zhen Gu in a statement, “so we could make the smart patch even smarter.”
The study found that the patch lowered blood glucose in mice for up to nine hours. As mice are less sensitive to insulin than humans, researchers suggest the patch can have a longer-lasting effect in diabetic patients. The patch emulates beta cells, which generate and store insulin in tiny sacks called vesicles. Beta cells play an important role in monitoring blood sugar levels and sending signals to release insulin into the bloodstream.
We constructed artificial vesicles to perform these same functions by using two materials that could easily be found in nature,” according to first author, Jiching Yu.
These substances were hyaluronic acid and 2-nitroimidazole (NI), which the researchers joined up to create a new molecule where one end was water-loving and the other was water-fearing. These molecules self-assembled into a vesicle within which researchers inserted a core of solid insulin and enzymes, which are specially designed to sense glucose.
When blood sugar levels increased, the enzymes converted the excess glucose molecules that crowded into the vesicles into a product called gluconic acid, a reaction that requires the consumption of oxygen. This means that the environment becomes starved of oxygen, which makes the water-loving NI molecules become water-fearing. Ultimately, this causes the vesicles to fall apart, sending insulin into the bloodstream.
The hard part of diabetes care is not the insulin shots, or the blood sugar checks, or the diet but the fact that you have to do them all several times a day every day for the rest of your life. If we can get these patches to work in people, it will be a game changer,” said co-senior author John Buse.
via Science Daily